What You Should Know:
– PsychoGenics Inc., a provider of AI-enabled phenotypic drug discovery and preclinical CRO services launches eCube®, a novel pharmaco-electroencephalography (“pharmacoEEG”) platform.
The platform supports phenotypic drug discovery, which unlike traditional target-based drug discovery, can identify novel treatments with multiple targets.
How eCube Works
eCube measures drug-induced changes to EEG spectra data and utilizes machine learning classifiers trained on reference drugs to predict the efficacy of novel compounds at the drug class (primary therapeutic indication) and subclass (primary mechanism of action) levels. In addition to predicting therapeutic applications for novel compounds, eCube can deliver translational biomarkers, providing an objective way to assess CNS activity, which is particularly important for compounds with unknown or complex mechanisms of action.
Similar to the Company’s AI-enabled, behavior-based platform, SmartCube®, eCube harnesses machine learning to identify CNS penetrant compounds and predict their therapeutic applications for neuropsychiatric disorders by comparing their EEG profiles to an extensive pharmacoEEG database comprised of hundreds of doses of CNS-active reference drugs.
